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Portfolio Companies Spun Out of
​The Center for Advancing Innovation Startup Challenges


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Oncolinx is developing the next generation of antibody-drug conjugates (ADCs): powerful, targeted cancer therapies that are more effective and have dramatically fewer side effects than current methods of cancer treatment.
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NeuroCognetix is a third-party solutions provider for the Magnetic Resonance Imaging (MRI) industry. The goal is to create innovative solutions which save medical imaging providers both time and money, while improving quality of care and patient experience.
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Cogentis discovers and develops first-in-class therapeutics that prevent neurodegeneration and restore brain function to benefit the lives of those patients and their families - curing the most debilitating of neurodegenerative disorders - Alzheimer's disease, dementia, and more. 
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Circumvent is developing a cure for Batten disease. Children affected by Batten disease present normally at birth, but succumb to psychomotor retardation around 11 to 18 months of age. As the disease progresses, neuronal death leads to complete blindness and degradation of brain activity until eventual death. 
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Angio360 is developing diagnostic products based on several blood biomarkers that are tied to blood vessel growth in tumors. The diagnostic tests can be used for early detection of tumors, measuring how well a cancer treatment is working, and monitoring tumor recurrence. 

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Hecate OncoSolutions' goal is to create effective treatments for patients with benign and malignant tumors developed with NF1; the company is developing “macar-A” (Schweinfurthin-A). Macar-A is a small molecule that affects only NF1 mutant cancer cells by disrupting their cytoskeleton without affecting normal cells.
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NeuroNostix is developing next-generation therapeutics for schizophrenia and bipolar disorder, striving for reduced side effects, better patient adherence, and fewer rehospitalizations.
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​NeuroExP is developing a device that can allow researchers to better study blast-induced traumatic brain injury (bTBI), thus optimizing the development of treatments.
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Beyond Barriers is finding new specific therapeutics that target inflammation and decrease the impact of injury following TBI.
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PRO-ARC offers a diagnostic test to increase patient access to industry-leading MS treatment by identifying those at risk for fatal complications.
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EncepHeal Therapeutics is developing first-in-class medicines to improve treatment of mental health disorders.
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Innovative Vascular Therapeutics is commercializing a therapeutic for stroke-related damage.
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AngioClast is utilizing molecular techniques to develop and revolutionize the treatment of brain cancer, restoring the health of many generations to come.
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​Great Lakes Neuroscience, Inc. is a virtual biopharmaceutical startup aimed at developing innovative therapies for neurodegenerative diseases.
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Estia Pharmaceuticals is a pharmaceutical research and development company focused on finding and commercializing the next generation of ADHD medications. 
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Bespoke Therapeutics develops targeted and efficient cancer treatments using virus-like-particle (VLP) technology and protein therapy. 
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Radial Genomics is a cancer diagnostics company using proprietary technology to diagnose and guide treatment in breast cancer patients through a novel, quantitative method of assessing changes in a patient's genetic material in response to cancer.
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​ProVivoX Inc. is specialized in providing a new kind of survival prognosis test, PhiPlex, to cancer patients.​
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We aspire to develop and commercialize a first-in-class FDA-approved In Vitro Diagnostics kit with predictive and prognostic capabilities for breast cancer.
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Orpheden Therapeutics is developing a personalized cancer therapy which mobilizes a patient's own immune system to target an individual’s specific tumor physiology without the harsh effects of current untargeted therapies.
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Taxotest, our flagship product, is a diagnostic biomarker that can be applied to a patient’s tumor sample to predict whether she would benefit from taxane-based chemotherapy.​
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OneTest Diagnostics is a Cambridge-based biotech startup developing a novel method of tracking response of cancer to therapy.​
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RNAissance is currently developing a treatment for Glioblastoma multiforme (GBM).​
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​AuTACA aims to develop a dual-purpose vaccine/drug therapy for metastatic cancer. 
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Nanobernetics is broadly-applicable, carbon nanotube technology that will revolutionize the field of precision medicine through diagnostic testing and prognostic monitoring.
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NanoRED is developing the next generation of immunotherapies capable of killing cancers and driving durable responses without systemic toxicity.
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​NanoSENSE will enable personal cancer biomarker detection. We will develop novel sensor technologies that detect DNA or other biological targets using a patented, miniaturized and label-free system that operates on personal smartphone devices.
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Latona Therapeutics is a biotechnology company developing a localized and targeted drug delivery system, using the licensed patent, which can minimize generic side-effects associated with chemotherapy administered to cancer patients.
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Precision Nanotech uses a platform technology developed by the NIH that can greatly reduce side effects, improve efficacy, and increase quality of life for patients
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​At Mesopharm, we envision to develop first-in-class biological therapies at a pre-clinical stage and accelerate their transition into the clinic.
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EDroneS is developing an autonomous robotic surveillance system for companies and houses using artificial intelligence and deep learning technology, which will rely on drones and rovers to act as platforms for the sensors and processing system during the surveillance process. 
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​ElectroKite is on a mission to utilize NASA’s vision control system to build a modular wind system that can be used to serve much smaller needs at an economical cost.
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Free Electron Designs is planning to be the answer for those that don't have access to electricity by using a NASA IP called Solid Oxide Fuel Cells (SOFC). 
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Genetoo is using NASA technology to combat the rising level of post-surgery infections, offering an innovative treatment that allows implantable, internal devices to fully repel bacteria.
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Jakuta is incorporating NASA’s patented piezoelectric material into shoes in which constant compressions generate energy that can be harnessed, stored and used to power critical devices such as lights and cell phones.
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Joule's mission is to develop a battery-free wearable product with enhanced analytical and sensory capabilities that will transform PT rehab.
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Maverick Drones is using advanced drone control technology created by NASA in order to improve science and math education in America.
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Minus Tau is using NASA technology to develop a smart helmet that will reduce the 30% of undiagnosed concussions every 1 in 5 contact sport athletes will receive in any given season. 
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Native Coatings was founded with the mission to create the best anti-corrosion coatings, using NASA technology.
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RA Tech is pursuing the patent rights for the technology, called Electrochemically Enhanced Mechanical Polishing (EEMP) with a focus on the Opthalmic industry.
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Stratodynamics invented the HiDRON using NASA technology to collect data, return home and redeploy, saving weather monitoring agencies money and reducing the negative impact on the environment. They are on the cutting edge of unmanned high altitude flight addressing a multitude of atmospheric applications.
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Tellus Aerospace is using NASA technology to reduce engine noise in jet aircraft.
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